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Adjuvant chemoradiotherapy versus radiotherapy alone in women

Background: The PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy versus pelvic radiotherapy alone for women with high-risk endometrial cancer. We updated the analysis to investigate patterns of recurrence and did a post-hoc survival analysis. Methods: In the multicentre randomised phase 3 PORTEC-3 …

Molecular Classification of the PORTEC-3 Trial for High-Risk

Purpose: The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for women with high-risk endometrial cancer (EC). Because The Cancer Genome Atlas …

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Final results of the international randomized PORTEC-3 trial …

5502 Background: Women with high-risk endometrial cancer (HREC) are at increased risk of distant metastasis and endometrial cancer-related death. The randomized PORTEC-3 intergroup trial was initiated to investigate the benefit of adjuvant chemotherapy during and after radiotherapy (CTRT) versus pelvic radiotherapy (RT) alone for women with HREC. …

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Instant Oncology: PORTEC-3

Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial. Lancet Oncol. 2018; 19 : 295-309

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Molecular Classification of the PORTEC-3 Trial for High-Risk

PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for women with high-risk endometrial cancer (EC). Because The Cancer Genome Atlas …

Better treatment for endometrial cancer: PORTEC 3

PORTEC-3 showed an improvement in "failure-free survival", which is the time from diagnosis to the cancer returning or death from the cancer. It is still an important result given that if the cancer returns it may not be possible to cure it.

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Multimodal Therapy for High-Risk or Locally Advanced …

In March 2018, The Lancet Oncology published the initial results from the PORTEC-3 trial. 1 PORTEC-3 was an open-label, multicenter, phase III randomized trial that compared …

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The PORTEC 3 study was supported in the UK by CRUK (C7925/A8659). Participation in the PORTEC-3 trial by ANZGOG and TROG were supported by the NHMRC Project Grant 570894 (2008) and by a Cancer Australia Grant (awarded through the 2011 round of the Priority-driven Collaborative Cancer Research Scheme and funded by Cancer Australia).

Adjuvant chemoradiotherapy versus radiotherapy alone in …

Methods. In the multicentre randomised phase 3 PORTEC-3 trial, women with high-risk endometrial cancer were eligible if they had International Federation of Gynaecology and Obstetrics (FIGO) 2009 stage I, endomeid grade 3 cancer with deep myometrial invasion or lymphovascular space invasion, or both; stage II or III disease; or stage I–III disease …

Adjuvant chemoradiotherapy versus radiotherapy alone for …

PORTEC-3 is registered with ISRCTN, number ISRCTN14387080, and ClinicalTrials.gov, number NCT00411138. Results: 686 women were enrolled between Nov 23, 2006, and Dec 20, 2013. 660 eligible patients were included in the final analysis, of whom 330 were assigned to chemoradiotherapy and 330 were assigned to radiotherapy. Median follow …

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Endometrial Cancer | New England Journal of Medicine

The PORTEC-3 trial showed that patients with stage III disease who received chemoradiation therapy followed by four cycles of carboplatin and paclitaxel chemotherapy had better overall and 5-year ...

HER2 Status in High-Risk Endometrial Cancers (PORTEC-3): …

In PORTEC-3, all but one (95.8%) of the HER2-positive ECs were classified as p53abn. Given this strong association, we additionally performed DISH on all p53abn EC with absent or any faint membranous staining to ascertain the HER2 status assignment by IHC was correct. In correspondence to the IHC results, none of these p53abn EC showed …

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(PDF) Évaluation in Vitro D'Un Nébuliseur À Tamis Vibrant, …

ÉVALUATION IN VITRO D'UN NÉBULISEUR À TAMIS VIBRANT, SYNCHRONISÉ SUR LES PHASES INSPIRATOIRE ET EXPIRATOIRE, D'UNE VENTILATION NON-INVASIVE À DEUX NIVEAUX DE PRESSION: ANALYSE DE LA DOSE INHALÉE Caroline BOTTEAU Étudiante Bachelor – Filière Physiothérapie Joana RODRIGUES DA SILVA Étudiante …

Instant Oncology: PORTEC-3

cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial. Lancet Oncol 2019;20(9):1273e1285. [3] Post CCB, de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, et al. Long-term toxicity and health-related quality of life after adjuvant chemoradiation therapy or radiation

Long-Term Toxicity and Health-Related Quality of Life After …

Purpose: The survival results of the PORTEC-3 trial showed a significant improvement in both overall and failure-free survival with chemoradiation therapy versus pelvic radiation therapy alone. The present analysis was performed to compare long-term adverse events (AE) and health-related quality of life (HRQOL). Methods and materials: In the study, …

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